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Tuesday, September 1, 2009
Bactroban
Form of production, composition and packaging
Bactroban Ointment 2%:
1 g contains 20 mg mupirocin;
15 g in a tube, in a carton box.
Ointment Bactroban intranasal 2%:
1 g contains 20 mg mupirocin;
3 g in a tube, in a cardboard pack ..
Pharmacological action
Bactroban is a broad-spectrum antibiotic for topical and local application. It is active against Gram-positive bacteria that cause the development of skin infections: Staphylococcus aureus (including strains resistant to methicillin, streptomycin, tetracycline, erythromycin, neomycin, fuzidovoy acid, lincomycin, Levomycetinum), as well as other strains of Staphylococcus spp., Streptococcus spp. (including coagulase-negative), Gram-negative bacteria: Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella catarrhalis, Bordetella pertussis, Pasteurella multocida, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii.
Pharmacokinetics
The level of systemic absorption of mupirocin to the surface of the skin and mucous membranes is extremely low. After absorption into the systemic circulation mupirocin is metabolized into an inactive monievuyu acid and excreted by the kidneys.
Indications
Ointment - bacterial infections of the skin (including impetigo, folliculitis, furunculosis, ecthyma);
- Secondary bacterial infections (including infected eczema, ulcers, minor wounds and burns);
- Prevention of infection in minor wounds and surgical incisions.
Ointment intranasal
- Staphylococcal carrier state in the nasal cavity (including strains of Staphylococcus aureus, multidrug-resistant and methicillin).
Dosing and Administration
The ointment is applied to the affected area of skin up to 3 times per day. Land may be covered with a bandage. The duration of treatment up to 10 days. Dosing regimens of the drug in adults, children and elderly and senile age did not differ.
Ointment intranasally injected into the nasal cavity 2-3 times / day. On the little finger taking a small amount of drug size of a match head and injected into one nostril. Just enter the drug in other nostril. Then his nostrils shut with two sides, with the ointment is distributed in the nasal passages. The average duration of treatment - 5-7 days. Dosing regimens for children and adults do not differ.
In children and seriously ill patients for the introduction of the ointment can be applied with a cotton swab sticks at the end.
Side effects
Perhaps: a burning sensation, tingling, itching at the site of application of ointment.
In applying intranasal ointment - rhinitis.
Contraindications
- Hypersensitivity to the drug.
Pregnancy and lactation
Bactroban not recommended during pregnancy, due to the lack of reliable clinical evidence supporting the safety of the drug in this period.
Cautions
Ointment for external use can not be used in ophthalmology and enter intranasally. When applying ointment to the skin should avoid getting it in her eyes.
Polyethylene glycol can be absorbed from open wounds and damaged skin and excreted by the kidneys, so the cream should be used with caution in the presence of severe or moderate renal impairment.
Nasal ointment can not be used in ophthalmology. When applying nasal ointment should avoid getting it in her eyes.
Overdose
At present, cases of overdose Bactroban not reported.
Conditions and terms of storage
The drug should be stored at temperatures not above 25 ° C.
Conditions of supply of pharmacies
The drug is released with a prescription.
Bactroban Ointment 2%:
1 g contains 20 mg mupirocin;
15 g in a tube, in a carton box.
Ointment Bactroban intranasal 2%:
1 g contains 20 mg mupirocin;
3 g in a tube, in a cardboard pack ..
Pharmacological action
Bactroban is a broad-spectrum antibiotic for topical and local application. It is active against Gram-positive bacteria that cause the development of skin infections: Staphylococcus aureus (including strains resistant to methicillin, streptomycin, tetracycline, erythromycin, neomycin, fuzidovoy acid, lincomycin, Levomycetinum), as well as other strains of Staphylococcus spp., Streptococcus spp. (including coagulase-negative), Gram-negative bacteria: Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella catarrhalis, Bordetella pertussis, Pasteurella multocida, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii.
Pharmacokinetics
The level of systemic absorption of mupirocin to the surface of the skin and mucous membranes is extremely low. After absorption into the systemic circulation mupirocin is metabolized into an inactive monievuyu acid and excreted by the kidneys.
Indications
Ointment - bacterial infections of the skin (including impetigo, folliculitis, furunculosis, ecthyma);
- Secondary bacterial infections (including infected eczema, ulcers, minor wounds and burns);
- Prevention of infection in minor wounds and surgical incisions.
Ointment intranasal
- Staphylococcal carrier state in the nasal cavity (including strains of Staphylococcus aureus, multidrug-resistant and methicillin).
Dosing and Administration
The ointment is applied to the affected area of skin up to 3 times per day. Land may be covered with a bandage. The duration of treatment up to 10 days. Dosing regimens of the drug in adults, children and elderly and senile age did not differ.
Ointment intranasally injected into the nasal cavity 2-3 times / day. On the little finger taking a small amount of drug size of a match head and injected into one nostril. Just enter the drug in other nostril. Then his nostrils shut with two sides, with the ointment is distributed in the nasal passages. The average duration of treatment - 5-7 days. Dosing regimens for children and adults do not differ.
In children and seriously ill patients for the introduction of the ointment can be applied with a cotton swab sticks at the end.
Side effects
Perhaps: a burning sensation, tingling, itching at the site of application of ointment.
In applying intranasal ointment - rhinitis.
Contraindications
- Hypersensitivity to the drug.
Pregnancy and lactation
Bactroban not recommended during pregnancy, due to the lack of reliable clinical evidence supporting the safety of the drug in this period.
Cautions
Ointment for external use can not be used in ophthalmology and enter intranasally. When applying ointment to the skin should avoid getting it in her eyes.
Polyethylene glycol can be absorbed from open wounds and damaged skin and excreted by the kidneys, so the cream should be used with caution in the presence of severe or moderate renal impairment.
Nasal ointment can not be used in ophthalmology. When applying nasal ointment should avoid getting it in her eyes.
Overdose
At present, cases of overdose Bactroban not reported.
Conditions and terms of storage
The drug should be stored at temperatures not above 25 ° C.
Conditions of supply of pharmacies
The drug is released with a prescription.
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Impetigo
Impetigo - pustular skin disease caused by streptococci and staphylococci. Pathogen penetrates through cracks and abrasions of the skin, the mouth of the hair follicles. Impetigo can occur as a primary disease or a complication of an existing dermatosis such as eczema, neurodermatitis (secondary impetigo). The development of the disease contribute to the micro, maceration, skin contamination, intense sweating, metabolic disorders (diabetes), vitamin deficiencies, weakened immune system (after a serious illness, etc.). Excrete streptococcus, staphylococcus (see Folliculitis), streptostafilokokkovoe, or vulgar, impetigo.
Streptococcaceae impetigo usually occurs in children and young women. It is characterized by the appearance flikten - flat bubbles up to 0,5-1 cm in diameter with clear or unclear content. Flikteny are scattered or in groups and surrounded by a narrow inflammatory rim. Tires flikten rapidly shrinking in thin yellowish crust, which in 5 - 7 days disappear, leaving a pink stain: rash often localized on the exposed parts of the body - face, legs, hands, but may be in other areas of skin. Children most often affects the corners of his mouth - streptogennaya Zayed, the wings of the nose, the folds of the skin ear shells, where he quickly unlock flikteny form painful cracks. Atypical variant of streptococcal impetigo is simply deprive a person, in which the skin (usually in children), there are pink spots of various sizes with small scales; on the site have authorized rash is temporary hyperpigmentation.
Streptostafilokokkovoe, or vulgar, impetigo usually occurs in children. The process, as with streptococcal impetigo, begins with education flikten to shrivel in the thick yellow-green rind. Eruptions are multiple, spread rapidly, are localized on the face, less often on the limbs, trunk: can occur when scabies, lice, etc. The disease is highly contagious. It may be accompanied limfangiitom, lymphadenitis may piokokkovoe kidney damage.
Treatment of common impetigo spend sulfanilamides, antibiotics, vitamins (A, C, group B): with prolonged duration - immunostimulatory therapy (autohemotherapy, protivostafilokokkovy immunoglobulin, staphylococcal toxoid). Flikteny treated with antiseptic: the skin around the lesions rubbed with an alcoholic solution of salicylic acid.
Prevention is the treatment of diseases that contribute to the development of impetigo, in compliance with the rules of personal hygiene, handling microtraumas antiseptic. In institutions a systematic sanitary-epidemiological supervision.
Streptococcaceae impetigo usually occurs in children and young women. It is characterized by the appearance flikten - flat bubbles up to 0,5-1 cm in diameter with clear or unclear content. Flikteny are scattered or in groups and surrounded by a narrow inflammatory rim. Tires flikten rapidly shrinking in thin yellowish crust, which in 5 - 7 days disappear, leaving a pink stain: rash often localized on the exposed parts of the body - face, legs, hands, but may be in other areas of skin. Children most often affects the corners of his mouth - streptogennaya Zayed, the wings of the nose, the folds of the skin ear shells, where he quickly unlock flikteny form painful cracks. Atypical variant of streptococcal impetigo is simply deprive a person, in which the skin (usually in children), there are pink spots of various sizes with small scales; on the site have authorized rash is temporary hyperpigmentation.
Streptostafilokokkovoe, or vulgar, impetigo usually occurs in children. The process, as with streptococcal impetigo, begins with education flikten to shrivel in the thick yellow-green rind. Eruptions are multiple, spread rapidly, are localized on the face, less often on the limbs, trunk: can occur when scabies, lice, etc. The disease is highly contagious. It may be accompanied limfangiitom, lymphadenitis may piokokkovoe kidney damage.
Treatment of common impetigo spend sulfanilamides, antibiotics, vitamins (A, C, group B): with prolonged duration - immunostimulatory therapy (autohemotherapy, protivostafilokokkovy immunoglobulin, staphylococcal toxoid). Flikteny treated with antiseptic: the skin around the lesions rubbed with an alcoholic solution of salicylic acid.
Prevention is the treatment of diseases that contribute to the development of impetigo, in compliance with the rules of personal hygiene, handling microtraumas antiseptic. In institutions a systematic sanitary-epidemiological supervision.
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Pharmacological action
Baktroban is a broad-spectrum antibiotic for topical and local application. It is active against Gram-positive bacteria that cause the development of skin infections: Staphylococcus aureus (including strains resistant to methicillin, streptomycin, tetracycline, erythromycin, neomycin, fuzidovoy acid, lincomycin, Levomycetinum), as well as other strains of Staphylococcus spp., Streptococcus spp. (including coagulase-negative), Gram-negative bacteria: Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella catarrhalis, Bordetella pertussis, Pasteurella multocida, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii.
Pharmacokinetics
The level of systemic absorption of mupirocin to the surface of the skin and mucous membranes is extremely low. After absorption into the systemic circulation mupirocin is metabolized into an inactive monievuyu acid and excreted by the kidneys.
Indications
Ointment
- Bacterial infections of the skin (including impetigo, folliculitis, furunculosis, ecthyma);
- Secondary bacterial infections (including infected eczema, ulcers, minor wounds and burns);
- Prevention of infection in minor wounds and surgical incisions.
Ointment intranasal
- Staphylococcal carrier state in the nasal cavity (including strains of Staphylococcus aureus, multidrug-resistant and methicillin).
Dosage regimen
The ointment is applied to the affected area of skin up to 3 times per day. Land may be covered with a bandage. The duration of treatment up to 10 days. Dosing regimens of the drug in adults, children and elderly and senile age did not differ.
Ointment intranasally injected into the nasal cavity 2-3 times / day. On the little finger taking a small amount of drug size of a match head and injected into one nostril. Just enter the drug in other nostril. Then his nostrils shut with two sides, with the ointment is distributed in the nasal passages. The average duration of treatment - 5-7 days. Dosing regimens for children and adults do not differ.
In children and seriously ill patients for the introduction of the ointment can be applied with a cotton swab sticks at the end.
Side effects
Perhaps: a burning sensation, tingling, itching at the site of application of ointment. In applying intranasal ointment - rhinitis.
Contraindications
- Hypersensitivity to the drug.
Pregnancy and lactation
Baktroban not recommended during pregnancy, due to the lack of reliable clinical evidence supporting the safety of the drug in this period.
Cautions
Ointment for external use can not be used in ophthalmology and enter intranasally. When applying ointment to the skin should avoid getting it in her eyes.
Polyethylene glycol can be absorbed from open wounds and damaged skin and excreted by the kidneys, so the cream should be used with caution in the presence of severe or moderate renal impairment.
Nasal ointment can not be used in ophthalmology. When applying nasal ointment should avoid getting it in her eyes.
Overdose
At present, cases of overdose Baktroban not reported.
Drug Interactions
Drug interaction drug Baktroban not described.
Conditions and terms of storage
The drug should be stored at temperatures not above 25 ° C.
Conditions of supply of pharmacies
The drug is released with a prescription.
Pharmacokinetics
The level of systemic absorption of mupirocin to the surface of the skin and mucous membranes is extremely low. After absorption into the systemic circulation mupirocin is metabolized into an inactive monievuyu acid and excreted by the kidneys.
Indications
Ointment
- Bacterial infections of the skin (including impetigo, folliculitis, furunculosis, ecthyma);
- Secondary bacterial infections (including infected eczema, ulcers, minor wounds and burns);
- Prevention of infection in minor wounds and surgical incisions.
Ointment intranasal
- Staphylococcal carrier state in the nasal cavity (including strains of Staphylococcus aureus, multidrug-resistant and methicillin).
Dosage regimen
The ointment is applied to the affected area of skin up to 3 times per day. Land may be covered with a bandage. The duration of treatment up to 10 days. Dosing regimens of the drug in adults, children and elderly and senile age did not differ.
Ointment intranasally injected into the nasal cavity 2-3 times / day. On the little finger taking a small amount of drug size of a match head and injected into one nostril. Just enter the drug in other nostril. Then his nostrils shut with two sides, with the ointment is distributed in the nasal passages. The average duration of treatment - 5-7 days. Dosing regimens for children and adults do not differ.
In children and seriously ill patients for the introduction of the ointment can be applied with a cotton swab sticks at the end.
Side effects
Perhaps: a burning sensation, tingling, itching at the site of application of ointment. In applying intranasal ointment - rhinitis.
Contraindications
- Hypersensitivity to the drug.
Pregnancy and lactation
Baktroban not recommended during pregnancy, due to the lack of reliable clinical evidence supporting the safety of the drug in this period.
Cautions
Ointment for external use can not be used in ophthalmology and enter intranasally. When applying ointment to the skin should avoid getting it in her eyes.
Polyethylene glycol can be absorbed from open wounds and damaged skin and excreted by the kidneys, so the cream should be used with caution in the presence of severe or moderate renal impairment.
Nasal ointment can not be used in ophthalmology. When applying nasal ointment should avoid getting it in her eyes.
Overdose
At present, cases of overdose Baktroban not reported.
Drug Interactions
Drug interaction drug Baktroban not described.
Conditions and terms of storage
The drug should be stored at temperatures not above 25 ° C.
Conditions of supply of pharmacies
The drug is released with a prescription.
Baktroban
International name:
Mupirocin (Mupirocin)
Group Affiliation:
Antibiotic
Description of the active substance (INN):
Mupirocin
Dosage form:
ointment for external use, nasal ointment
Pharmacological Effects:
Bacteriostatic broad-spectrum antibiotic for local use. Inhibits bacterial protein synthesis by reversible and specific binding to isoleucyl-RNA synthetase transport. -Factor for pathogens of skin infections: Staphylococcus aureus (including for strains resistant to methicillin), Staphylococcus epidermidis, Staphylococcus saprophyticus and Streptococcus pyogenes (including koagulazanegativnye). No cross-resistance with chloramphenicol, erythromycin, fuzidovoy acid, gentamicin, lincomycin, methicillin, neomycin, streptomycin, tetracycline.
Indications:
In Dermatology: impetigo, folliculitis, furunculosis, eczema, infected dermatitis, ecthyma, traumatic injuries of skin, including wounds, bruises, burns, prevention of wound infection. In ENT: staphylococcal infection of the nasal cavity.
Contraindications:
Hypersensitivity, pregnancy, laktatsii.C caution. Renal failure.
Side effects:
Burning, itching at the site of application.
Dosage and administration:
In dermatology: an ointment for external use, is applied to affected skin 3 times a day, if necessary, impose aseptic bandage treatment - up to 10 days. In otolaryngology: nasal ointment in the nasal passages, 2-3 times a day, a course of treatment - 5-7 days.
Cautions:
Be used in accordance with strict dosage form indications. Avoid contact with eyes. Polyethylene glycol, which is part of ointment for external use, is absorbed from open wounds and damaged skin and excreted by the kidneys (used with caution in the presence of severe renal failure).
Mupirocin (Mupirocin)
Group Affiliation:
Antibiotic
Description of the active substance (INN):
Mupirocin
Dosage form:
ointment for external use, nasal ointment
Pharmacological Effects:
Bacteriostatic broad-spectrum antibiotic for local use. Inhibits bacterial protein synthesis by reversible and specific binding to isoleucyl-RNA synthetase transport. -Factor for pathogens of skin infections: Staphylococcus aureus (including for strains resistant to methicillin), Staphylococcus epidermidis, Staphylococcus saprophyticus and Streptococcus pyogenes (including koagulazanegativnye). No cross-resistance with chloramphenicol, erythromycin, fuzidovoy acid, gentamicin, lincomycin, methicillin, neomycin, streptomycin, tetracycline.
Indications:
In Dermatology: impetigo, folliculitis, furunculosis, eczema, infected dermatitis, ecthyma, traumatic injuries of skin, including wounds, bruises, burns, prevention of wound infection. In ENT: staphylococcal infection of the nasal cavity.
Contraindications:
Hypersensitivity, pregnancy, laktatsii.C caution. Renal failure.
Side effects:
Burning, itching at the site of application.
Dosage and administration:
In dermatology: an ointment for external use, is applied to affected skin 3 times a day, if necessary, impose aseptic bandage treatment - up to 10 days. In otolaryngology: nasal ointment in the nasal passages, 2-3 times a day, a course of treatment - 5-7 days.
Cautions:
Be used in accordance with strict dosage form indications. Avoid contact with eyes. Polyethylene glycol, which is part of ointment for external use, is absorbed from open wounds and damaged skin and excreted by the kidneys (used with caution in the presence of severe renal failure).
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